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Metabolic Research Peptide
MOTS-c (20mg)
Mitochondrial-derived peptide · Research-grade, Australia
In stock · dispatched Australia-wide
View & buy on store →About MOTS-c
MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA. It is studied for its role in metabolic homeostasis, insulin sensitivity, and the cellular stress response in laboratory and pre-clinical models.
MOTS-c is unusual among research peptides in being mitochondrially encoded rather than nuclear, which shapes how it tends to be studied: assays generally run against a metabolic readout — respiration rate, substrate utilisation, AMPK phosphorylation state — rather than a receptor-binding endpoint. Those readouts are slower and noisier than a binding assay, so replicate count does more for the result than concentration range does. The 20 mg presentation is sized for that: enough material for a properly replicated metabolic panel drawn from one lot.
Molecular & physical profile
| Compound | MOTS-c |
|---|---|
| Category | Metabolic |
| CAS Number | 1627580-64-6 |
| Form | Lyophilised Powder |
| Appearance | White to off-white solid |
| Quantity | 20 mg per vial |
| Purity | 99.324% (this batch) |
| Batch | CS-mc20-2540 |
| Analytical methods | HPLC (purity), mass spectrometry (identity) |
| Solubility (research) | Reconstitutes in bacteriostatic or sterile water |
Batch-specific analytical values are recorded on the Certificate of Analysis supplied with the compound.
Reconstitution & handling
MOTS-c is a 16-amino-acid peptide supplied as a lyophilised powder, and it reconstitutes readily in bacteriostatic or sterile water without the slow dissolution seen with acylated peptides. At 20 mg a 4 mL reconstitution gives a 5 mg/mL stock, which sits a convenient two dilution steps above the concentrations most cell-culture metabolic work calls for.
Stock concentrations available from a single 20 mg vial:
| 2 mL of diluent | 10 mg/mL stock |
|---|---|
| 2.5 mL of diluent | 8 mg/mL stock |
| 4 mL of diluent | 5 mg/mL stock |
| 8 mL of diluent | 2.5 mg/mL stock |
In-vitro stock concentrations for laboratory dilution work. Not dosing information.
Storage & stability
- Lyophilised powder — -20 °C — protect from light & moisture.
- Reconstituted solution — 2–8 °C — use within 28 days.
- Handling — minimise freeze–thaw cycles; keep vials sealed until use.
- Aliquoting — metabolic panels are typically run in blocks over successive days, so aliquot to per-block volumes at reconstitution rather than drawing repeatedly from one thawed vial.
How the 20mg format differs from the 10mg
Identical compound and identical analytical methods to the 10 mg presentation — the fill weight is the only variable. The 10 mg vial covers a single metabolic assay or a pilot to establish whether an effect is measurable at all. The 20 mg vial covers the replicated follow-up, where the same conditions are repeated enough times to separate signal from the day-to-day variance that respiration and substrate-utilisation readouts carry. Since that variance is the main obstacle in this kind of work, replicate count is usually the better place to spend material than concentration range.
For extended or multi-condition panels the 40 mg presentation takes the same logic further.
Quality & testing
Every batch supplied by Vital Research Labs is analysed by an independent third-party laboratory. Purity is confirmed by high-performance liquid chromatography (HPLC) and identity by mass spectrometry (MS). This batch is verified at 99.391% purity, and a Certificate of Analysis is available for the batch so researchers can verify exactly what they are working with.
Shipping within Australia
MOTS-c is dispatched from within Australia to Australian research customers, packaged discreetly and appropriately for a lyophilised research compound. Orders are processed on receipt of payment via bank transfer.
Frequently asked questions
Is MOTS-c (20mg) available in Australia for research?
Yes. Vital Research Labs supplies research-grade MOTS-c (20mg) to Australian research customers, dispatched domestically. It is provided strictly for in-vitro laboratory research and is not for human or veterinary use.
What purity is your MOTS-c (20mg)?
This batch is verified at 99.324% purity by third-party analytical testing (HPLC for purity, mass spectrometry for identity). A Certificate of Analysis is available for the batch.
How is MOTS-c (20mg) tested?
Each batch is analysed by an independent third-party laboratory using HPLC to confirm purity and mass spectrometry to confirm identity. Batch-specific values are recorded on the Certificate of Analysis.
How should MOTS-c (20mg) be stored?
The lyophilised powder is stored at -20 degrees C, protected from light and moisture. Once reconstituted for research it is kept at 2-8 degrees C and typically used within 28 days.
Is MOTS-c (20mg) intended for human use?
No. MOTS-c (20mg) supplied by Vital Research Labs is intended strictly for in-vitro laboratory research and development. It is not a medicine or therapeutic good and is not for human consumption, veterinary use, or clinical application.
Where can I buy MOTS-c in Australia?
Vital Research Labs supplies MOTS-c from Australian stock, dispatched from New South Wales. Orders placed before the daily cut-off are dispatched the same business day, Monday to Friday, with tracked delivery Australia-wide including Sydney, Melbourne, Brisbane, Perth and Adelaide.
How long does delivery take?
Orders are dispatched the same business day payment is confirmed, Monday to Friday. Weekend and public holiday orders are dispatched the next business day. Standard and express options are available, and express shipping is free on orders over $200. Every order is sent tracked.
Is packaging discreet?
Yes. All orders are packed in plain, unbranded outer packaging with no indication of the contents, and sent tracked via Australia Post or an equivalent carrier.
What payment methods do you accept?
We accept Visa, Mastercard and American Express, plus Apple Pay and Google Pay, all taken instantly at checkout. Bank transfer is also available if you prefer.
What stock concentrations can a 20mg MOTS-c vial be reconstituted to?
Reconstituting 20mg in 2mL of bacteriostatic water gives 10mg/mL; 2.5mL gives 8mg/mL; 4mL gives 5mg/mL; and 8mL gives 2.5mg/mL. These are in-vitro stock concentrations for laboratory dilution work only.
Why choose the 20mg MOTS-c vial over the 10mg?
For replicate count rather than concentration range. Metabolic readouts such as respiration rate and substrate utilisation carry more day-to-day variance than receptor-binding assays, so results depend more on repetition than on covering a wide concentration ladder. The 20mg fill supports a properly replicated panel from one lot and batch number.
Does MOTS-c reconstitute differently from larger peptides?
It dissolves more readily. MOTS-c is a 16-amino-acid peptide with no acylation, so it goes into bacteriostatic or sterile water without the slow clearing seen with modified peptides such as semaglutide. Add diluent gently against the vial wall regardless and avoid vortexing.